Coding & Interoperability


Connect medication knowledge.

Preserve clinical meaning.


RxPedia combines drug identifiers, therapeutic classifications, and medical concepts to help connect medication intelligence with the terminology used in your organization.

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Your system

Agreed RxPedia interface

Structured clinical information

Your clinical workflow

Drug Proprietary Identifiers

Connect medication concepts with international and national identifiers.

Therapeutic Classification System

Organize drugs across multiple therapeutic classes and hierarchy levels.

Medical Proprietary Identifiers

Relate drug products to diagnoses and other health-related concepts.

Three connected information structures


RxPedia Coding & Interoperability brings together Drug Proprietary Identifiers, a Therapeutic Classification System, and Medical Proprietary Identifiers. Each addresses a different question: which medication is being represented, how it is classified, and which clinical concepts relate to it.


These structures support the connection between medication knowledge and clinical systems. A cross-reference makes a relationship available for interpretation; it should not be treated as proof that two concepts are interchangeable in every context.

Drug Proprietary Identifiers

RxPedia Drug Proprietary Identifiers connect medication concepts with international and local medication terminology. Cross-references include ATC, NDC, RxNorm, SNOMED CT, and relevant national medication identifiers, according to the mapping scope provided for the implementation.


This creates a way to relate identifiers used by different systems to RxPedia medication knowledge. It can support medication identification and the preparation of data for a screening or information-retrieval workflow.


The source systems represent medications at different levels. An ingredient, a clinical drug, a branded product, and a package identifier are not automatically equivalent. Review the intended concept level, formulation, strength, and other relevant attributes before using a cross-reference in a clinical workflow.


NLM is the U.S. National Library of Medicine, not a standalone medication coding system. When specifying NLM-related terminology requirements, identify the actual vocabulary or resource, such as RxNorm, and the identifiers needed by the integration.

Therapeutic Classification System

RxPedia's Therapeutic Classification System provides multiple ways to categorize medications for formulary organization, navigation, and drug selection workflows. A medication can belong to multiple therapeutic classes, with links to drug concepts at different levels of the hierarchy.


This allows a system to present a broader category and then connect it to more specific classes or medication concepts. Multiple class membership helps preserve different clinically relevant perspectives instead of forcing every medication into a single category.


Classification can help organize a formulary; it does not establish a local formulary decision, reimbursement rule, or recommendation to prescribe a particular medication. Likewise, shared class membership does not by itself establish that medications are interchangeable or that their combined use is inappropriate.

Medical Proprietary Identifiers

Begin with the medication or medical code supplied by the host system. Identify its vocabulary and version, relate it to the appropriate RxPedia concept, and confirm that the relationship is suitable for the intended use.


The resulting concept can then support an available knowledge or screening service. Present the returned clinical information in the host workflow with the context and limitations needed for professional interpretation.


Not every source entry will necessarily have a usable match. Agree how your system handles missing identifiers, ambiguous relationships, unsupported concepts, and mappings that need review. An unresolved mapping must not silently become a completed clinical check.

From source identifier to clinical workflow


RxPedia Medical Proprietary Identifiers provide a specialized vocabulary relating drug products to diagnoses and other health-related concepts. These relationships support the representation of clinical context used in disease-related decision-support and dosing workflows.


The vocabulary includes cross-references between RxPedia medical concepts and ICD-9-CM, SNOMED CT, ICD-10-CM, and ICD-10-PCS within the applicable mapping scope. The kind of relationship must be preserved: ICD-10-CM describes diagnoses, while ICD-10-PCS describes inpatient procedures. A procedure code must not be treated as an equivalent disease identifier.


ICD-9-CM relationships can be relevant to legacy records. Confirm the code system, edition, jurisdiction, and whether the record represents a diagnosis or procedure before selecting a mapping.


Terminology relationships are distinct from an executable clinical screening module. Their presence does not mean that disease contraindication screening or dose screening is currently included in your RxPedia deployment. Confirm the actual modules and intended use separately.

Evaluate mapping quality and implementation fit


Use representative synthetic examples from your actual coding environment. Include ingredient-level and product-level records, relevant local identifiers, multiple class memberships, legacy codes, and unmatched entries.


Ask for the available mapping scope, source and target versions, relationship types, maintenance arrangements, permitted uses, and any licensing requirements. Where mappings are used for clinical functions, validate their suitability with both clinical and technical reviewers.


Cross-references may simplify parts of an integration, but implementation effort depends on the source data and workflow. No fixed reduction in integration time is implied.

Questions about coding and interoperability

Start an interoperability discussion

Bring your medication and clinical terminology requirements to an integration discussion. Review the available cross-references, classification structure, clinical scope, and implementation responsibilities before connecting them to a live workflow.


Discuss an Integration